Questioning the relevance of circulating cardiac progenitor cells in cardiac regeneration
نویسندگان
چکیده
منابع مشابه
Questioning the relevance of circulating cardiac progenitor cells in cardiac regeneration.
Regeneration of injured myocardium would offer relief to millions of patients with left ventricular dysfunction. Cell implantation and induction of stem cell-mediated myocardial self-repair represent potential means to achieve myocardial regeneration [1,2]. The latter requires homing of cardiogenic cells to diseased myocardium or activation of resident cardiogenic stem cells. Both mechanisms ha...
متن کاملHeart factory or fiction?: cardiac progenitor cells and regeneration.
I n the Christian tradition, the doctrine of regeneration considers the " deceitful…and wicked " heart a vessel for accepting God and thereby being born again. Indeed, many cultures have invested the heart with powers well beyond its biological role in maintaining systemic perfusion. However, the capacity of the heart for renewal was limited to metaphor until relatively recently, when science r...
متن کاملINHIBITION OF WNT3A DIMINISHED ANGIOGENIC DIFFERENTIATION CAPACITY OF RAT CARDIAC PROGENITOR CELLS
Background & Aims: Myocardial infarction is a leading cause of human mortality in industrialized and developing societies. Limited restorative ability of of cardiomyocytes after ischemic changes can causes extensive damage lead to prominent chronic heart failure. At present, the application of certain drugs is touted as one of the main available approaches to inhibit the spread of the lesion an...
متن کاملThe Role of Cardiac Side Population Cells in Cardiac Regeneration
The heart has a limited ability to regenerate. It is important to identify therapeutic strategies that enhance cardiac regeneration in order to replace cardiomyocytes lost during the progression of heart failure. Cardiac progenitor cells are interesting targets for new regenerative therapies because they are self-renewing, multipotent cells located in the heart. Cardiac side population cells (c...
متن کاملResident Cardiac Progenitor Cells
Neufeld Cardiac Research Institute, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel Abstract Resident cardiac stem/progenitor cells are implicated in cell replacement, repair and maintenance of the myocardium. These cells are already committed to a specific cardiomyogenic pathway. Stimulation of these cells in injured hearts can open new options in cardiovascular regenerative...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2005
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2005.09.010